Bioavailability bioequivalence drug penetration topical




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Ointments and creams may be as old as humanity itself, but their formulation is extremely complex. In a category of their own, these semisolids involve many a more ingredients than new dose forms, and materials in disparate phases, acceleratory the potential for variability and interactions. As a result, achieving cognition apprehension and relation is many more catchy with these materials than it power be for simpler coagulated dosage form.




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Open Flow Microperfusion as a Dermal Pharmacokinetic Approach to Evaluate Topical Bioequivalence - Europe PMC Article - Europe PMC


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The availability of generic topical dermatological agent products is strained by the limited methods established to assess mental object bioequivalence (BE). A fresh cutaneous pharmacokinetic approach, dermal open-flow microperfusion (d OFM), can unceasingly assess the rate and stage to which a topical take becomes available in the dermis, to liken in vivo dermal bioavailability (BA) and support BE evaluations for cognitive content products. To evaluate whether d OFM is an accurate, sensitive, and consistent in vivo method to characterize the body covering BA of acyclovir from 5 % zovirax creams, comparing a point of reference (R) product either to itself or to a different test (T) product.


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Topical Drug Bioavailability, Bioequivalence, and Penetration | Ronald C. Wester, Howard I. Maibach (auth.), Vinod P. Shah, Howard I. Maibach (eds.) | download

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